Well, first of all smoke it first otherwise the rub prevents the rub from penetrating. Then I start with brown sugar, add a good vinegar, salt, pepper, garlic powder, celery seed, red pepper flakes, mustard, what am I forgetting? I don't measure, just add ingredients to suit my taste.
After smoking I apply the rub and wrap the brisket in foil and refrig overnight. Then 3 hours in the oven at low heat and serve.